And if they have diarrhea SIBO – coffee, caffeine stimulates peristalsis action. It drains the adrenals. It interferes with good sleep. "Oh, but, doc, I just have one cup before 9:00 in the morning!". Yeah, well, there's no law that says it's detoxed [before the end of the day]. Coffee tends to wake you up at 3:00 a.m.